Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety and panic-associated circuitry. Recent studies support a role for the orexin system and in particular the orexin 1 receptor (OX1R) in coordina...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D., Shekhar, Anantha, Johnson, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465257/
https://ncbi.nlm.nih.gov/pubmed/28649201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00357
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