Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety and panic-associated circuitry. Recent studies support a role for the orexin system and in particular the orexin 1 receptor (OX1R) in coordina...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D., Shekhar, Anantha, Johnson, Philip L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465257/
https://ncbi.nlm.nih.gov/pubmed/28649201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00357
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares