Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans. While selective blockade of OX2R seems to be sufficient to initi...

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Detaylı Bibliyografya
Asıl Yazarlar: Dugovic, Christine, Shelton, Jonathan E., Yun, Sujin, Bonaventure, Pascal, Shireman, Brock T., Lovenberg, Timothy W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2014
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924048/
https://ncbi.nlm.nih.gov/pubmed/24592208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00028
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