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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism
In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans. While selective blockade of OX2R seems to be sufficient to initi...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Frontiers Media S.A.
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924048/ https://ncbi.nlm.nih.gov/pubmed/24592208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00028 |
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