Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

Por Fischer, Wolfgang, Franke, Heike, Krügel, Ute, Müller, Heiko, Dinkel, Klaus, Lord, Brian, Letavic, Michael A., Henshall, David C., Engel, Tobias
Publicado no PLoS One (2016)

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

Por Savall, Brad M., Wu, Duncan, De Angelis, Meri, Carruthers, Nicholas I., Ao, Hong, Wang, Qi, Lord, Brian, Bhattacharya, Anindya, Letavic, Michael A.
Publicado no ACS Med Chem Lett (2015)

Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [(11)C]GSK189254 in anesthetized baboon

Por Logan, Jean, Carruthers, Nicholas I., Letavic, Michael A., Sands, Steven, Jiang, Xiaohui, Shea, Colleen, Muench, Lisa, Xu, Youwen, Carter, Pauline, King, Payton, Fowler, Joanna S.
Publicado em 2012

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

Por Bhattacharya, Anindya, Wang, Qi, Ao, Hong, Shoblock, James R, Lord, Brian, Aluisio, Leah, Fraser, Ian, Nepomuceno, Diane, Neff, Robert A, Welty, Natalie, Lovenberg, Timothy W, Bonaventure, Pascal, Wickenden, Alan D, Letavic, Michael A
Publicado em 2013

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X(7) Antagonists

Por Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Publicado em 2013

Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

Por Letavic, Michael A., Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J., Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Fraser, Ian C., Kramer, Michelle L., Lord, Brian, Lovenberg, Timothy W., Li, Lilian Y., Ly, Kiev S., Mcallister, Heather, Mani, Neelakandha S., Morton, Kirsten L., Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R., Sands, Steven B., Shah, Chandra R., Shelton, Jonathan E., Snook, Sandra S., Swanson, Devin M., Xiao, Wei
Publicado no ACS Med Chem Lett (2015)