Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

[Image: see text] The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H(3) receptor antagonists is described. The compounds described are high affinity histamine H(3) antagonists. Optimization of the physical properties of these histamine H(3) antagonists le...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Letavic, Michael A., Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J., Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Fraser, Ian C., Kramer, Michelle L., Lord, Brian, Lovenberg, Timothy W., Li, Lilian Y., Ly, Kiev S., Mcallister, Heather, Mani, Neelakandha S., Morton, Kirsten L., Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R., Sands, Steven B., Shah, Chandra R., Shelton, Jonathan E., Snook, Sandra S., Swanson, Devin M., Xiao, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394347/
https://ncbi.nlm.nih.gov/pubmed/25893048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5005156
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