Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H(3) antagonist

1. 1-[4-(3-piperidin-1-yl-propoxy)-benzyl]-piperidine (JNJ-5207852) is a novel, non-imidazole histamine H(3) receptor antagonist, with high affinity at the rat (pK(i)=8.9) and human (pK(i)=9.24) H(3) receptor. JNJ-5207852 is selective for the H(3) receptor, with negligible binding to other receptors...

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Detalhes bibliográficos
Main Authors: Barbier, A J, Berridge, C, Dugovic, C, Laposky, A D, Wilson, S J, Boggs, J, Aluisio, L, Lord, B, Mazur, C, Pudiak, C M, Langlois, X, Xiao, W, Apodaca, R, Carruthers, N I, Lovenberg, T W
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575430/
https://ncbi.nlm.nih.gov/pubmed/15466448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705964
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