Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

Emerging data continues to point towards a relationship between neuroinflammation and neuropsychiatric disorders. ATP-induced activation of P2X7 results in IL-1β release causing neuroinflammation and microglial activation. This study describes the in-vitro and in-vivo neuropharmacology of a novel br...

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Publicado no:Neuropsychopharmacology
Main Authors: Bhattacharya, Anindya, Lord, Brian, Grigoleit, Jan-Sebastian, He, Yingbo, Fraser, Ian, Campbell, Shannon N., Taylor, Natalie, Aluisio, Leah, O’Connor, Jason C., Papp, Mariusz, Chrovian, Christa, Carruthers, Nicholas, Lovenberg, Timothy W., Letavic, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224414/
https://ncbi.nlm.nih.gov/pubmed/30026598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0141-6
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