Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X(7) Antagonists

[Image: see text] The synthesis and preclinical characterization of two novel, brain penetrating P2X(7) compounds will be described. Both compounds are shown to be high potency P2X(7) antagonists in human, rat, and mouse cell lines and both were shown to have high brain concentrations and robust rec...

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Main Authors: Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027403/
https://ncbi.nlm.nih.gov/pubmed/24900687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400040v
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