The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

Antagonizing the action of the human nuclear xenobiotic receptor pregnane X receptor (PXR) may have important clinical implications in preventing drug-drug interactions and improving therapeutic efficacy. We provide evidence that a naturally occurring phytoestrogen, coumestrol, is an antagonist of t...

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Publicat a:Mol Endocrinol
Autors principals: Wang, Hongwei, Li, Hao, Moore, Linda B., Johnson, Michael D. L., Maglich, Jodi M., Goodwin, Bryan, Ittoop, Olivia R. R., Wisely, Bruce, Creech, Katrina, Parks, Derek J., Collins, Jon L., Willson, Timothy M., Kalpana, Ganjam V., Venkatesh, Madhukumar, Xie, Wen, Cho, Sool Y., Roboz, John, Redinbo, Matthew, Moore, John T., Mani, Sridhar
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419551/
https://ncbi.nlm.nih.gov/pubmed/18096694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0218
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