Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR

The pregnane X receptor (PXR) is a master regulator of xenobiotic metabolism, and its activity is critical toward understanding the pathophysiology of several diseases, including inflammation, cancer, and steatosis. Previous studies have demonstrated that ketoconazole binds to ligand-activated PXR a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Li, Hao, Redinbo, Matthew R., Venkatesh, Madhukumar, Ekins, Sean, Chaudhry, Anik, Bloch, Nicolin, Negassa, Abdissa, Mukherjee, Paromita, Kalpana, Ganjam, Mani, Sridhar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650402/
https://ncbi.nlm.nih.gov/pubmed/23525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455485
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak