Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR

The pregnane X receptor (PXR) is a master regulator of xenobiotic metabolism, and its activity is critical toward understanding the pathophysiology of several diseases, including inflammation, cancer, and steatosis. Previous studies have demonstrated that ketoconazole binds to ligand-activated PXR a...

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Detalhes bibliográficos
Main Authors: Li, Hao, Redinbo, Matthew R., Venkatesh, Madhukumar, Ekins, Sean, Chaudhry, Anik, Bloch, Nicolin, Negassa, Abdissa, Mukherjee, Paromita, Kalpana, Ganjam, Mani, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650402/
https://ncbi.nlm.nih.gov/pubmed/23525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455485
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