Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR

The pregnane X receptor (PXR) is a master regulator of xenobiotic metabolism, and its activity is critical toward understanding the pathophysiology of several diseases, including inflammation, cancer, and steatosis. Previous studies have demonstrated that ketoconazole binds to ligand-activated PXR a...

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Bibliographische Detailangaben
Hauptverfasser: Li, Hao, Redinbo, Matthew R., Venkatesh, Madhukumar, Ekins, Sean, Chaudhry, Anik, Bloch, Nicolin, Negassa, Abdissa, Mukherjee, Paromita, Kalpana, Ganjam, Mani, Sridhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650402/
https://ncbi.nlm.nih.gov/pubmed/23525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455485
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