Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR

The pregnane X receptor (PXR) is a master regulator of xenobiotic metabolism, and its activity is critical toward understanding the pathophysiology of several diseases, including inflammation, cancer, and steatosis. Previous studies have demonstrated that ketoconazole binds to ligand-activated PXR a...

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Main Authors: Li, Hao, Redinbo, Matthew R., Venkatesh, Madhukumar, Ekins, Sean, Chaudhry, Anik, Bloch, Nicolin, Negassa, Abdissa, Mukherjee, Paromita, Kalpana, Ganjam, Mani, Sridhar
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650402/
https://ncbi.nlm.nih.gov/pubmed/23525103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455485
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