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Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database
BACKGROUND: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. OBJECTIVES: As part of an evaluation of different approaches to predict compound affinity for nuclear ho...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Institute of Environmental Health Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957921/ https://ncbi.nlm.nih.gov/pubmed/20558333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1001930 |
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