Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

BACKGROUND: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. OBJECTIVES: As part of an evaluation of different approaches to predict compound affinity for nuclear ho...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Kortagere, Sandhya, Krasowski, Matthew D., Reschly, Erica J., Venkatesh, Madhukumar, Mani, Sridhar, Ekins, Sean
Format: Artigo
Jezik:Inglês
Izdano: National Institute of Environmental Health Sciences 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957921/
https://ncbi.nlm.nih.gov/pubmed/20558333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1001930
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki