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Evolution of pharmacologic specificity in the pregnane X receptor
BACKGROUND: The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the pharmacophores for activation of human, mouse, rat, rabbit, chicken, and zebrafish PXRs, using a common set of s...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2358886/ https://ncbi.nlm.nih.gov/pubmed/18384689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-103 |
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