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Evolution of pharmacologic specificity in the pregnane X receptor
BACKGROUND: The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the pharmacophores for activation of human, mouse, rat, rabbit, chicken, and zebrafish PXRs, using a common set of s...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2358886/ https://ncbi.nlm.nih.gov/pubmed/18384689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-103 |
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