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Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases

Activated ERK translocates to the nucleus to regulate transcription. Spatiotemporal aspects of this response dictate biological consequences and are influenced by dual-specificity phosphatases (DUSPs) that can scaffold and dephosphorylate ERK. In HeLa cells, GnRH causes transient and protein kinase...

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Bibliografske podrobnosti
izdano v:Mol Endocrinol
Main Authors: Armstrong, Stephen Paul, Caunt, Christopher James, McArdle, Craig Alexander
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419268/
https://ncbi.nlm.nih.gov/pubmed/19179479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0333
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