Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors

Gonadotropin-releasing hormone (GnRH) acts via seven transmembrane receptors to stimulate gonadotropin secretion. Sustained stimulation desensitizes GnRH receptor (GnRHR)-mediated gonadotropin secretion, and this underlies agonist use in hormone-dependent cancers. Since type I mammalian GnRHR do not...

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Detalhes bibliográficos
Main Authors: Finch, Ann R., Caunt, Christopher J., Armstrong, Stephen P., McArdle, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Receptors and Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740399/
https://ncbi.nlm.nih.gov/pubmed/19587220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00166.2009
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