Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling: DOES THE ERK SIGNALING PATHWAY DECODE GnRH PULSE FREQUENCY?

Gonadotropin-releasing hormone (GnRH) acts via G-protein-coupled receptors on gonadotrophs to stimulate synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. It is secreted in pulses, and its effects depend on pulse frequency, but decoding mechanisms are unknown. Here we h...

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Detalhes bibliográficos
Main Authors: Armstrong, Stephen P., Caunt, Christopher J., Fowkes, Robert C., Tsaneva-Atanasova, Krasimira, McArdle, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915671/
https://ncbi.nlm.nih.gov/pubmed/20507982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115964
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