Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Santamaria, Salvatore, Fedorov, Oleg, McCafferty, John, Murphy, Gillian, Dudhia, Jayesh, Nagase, Hideaki, Yamamoto, Kazuhiro
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419085/
https://ncbi.nlm.nih.gov/pubmed/28306378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1304341
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