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LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage
Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Federation of American Societies for Experimental Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545526/ https://ncbi.nlm.nih.gov/pubmed/23064555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-216671 |
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