Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4): FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING

Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading enzymes. We have recently found that ADAMTS-5 is r...

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Bibliografiske detaljer
Main Authors: Yamamoto, Kazuhiro, Owen, Kathryn, Parker, Andrew E., Scilabra, Simone D., Dudhia, Jayesh, Strickland, Dudley K., Troeberg, Linda, Nagase, Hideaki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945312/
https://ncbi.nlm.nih.gov/pubmed/24474687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545376
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