MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity associates with diseases such as arthritis, cancer, atherosclerosis and fibrosis. The wide range of MMP-13 proteolytic capacity suggests that it is a powerful, potentially destructive proteinase...

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Vydáno v:Matrix Biol
Hlavní autoři: Yamamoto, Kazuhiro, Okano, Hiroshi, Miyagawa, Wakako, Visse, Robert, Shitomi, Yasuyuki, Santamaria, Salvatore, Dudhia, Jayesh, Troeberg, Linda, Strickland, Dudley K., Hirohata, Satoshi, Nagase, Hideaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146981/
https://ncbi.nlm.nih.gov/pubmed/27084377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2016.03.007
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