LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yamamoto, Kazuhiro, Troeberg, Linda, Scilabra, Simone D., Pelosi, Michele, Murphy, Christopher L., Strickland, Dudley K., Nagase, Hideaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2013
Pynciau:
Research Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545526/
https://ncbi.nlm.nih.gov/pubmed/23064555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-216671
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