LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Yamamoto, Kazuhiro, Troeberg, Linda, Scilabra, Simone D., Pelosi, Michele, Murphy, Christopher L., Strickland, Dudley K., Nagase, Hideaki
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2013
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545526/
https://ncbi.nlm.nih.gov/pubmed/23064555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-216671
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk