Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

Adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5 is the multi-domain metalloproteinase that most potently degrades aggrecan proteoglycan in the cartilage and its activity is implicated in the development of osteoarthritis (OA). To generate specific exosite inhibitors for...

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Bibliographic Details
Published in:Biochem J
Main Authors: Santamaria, Salvatore, Yamamoto, Kazuhiro, Botkjaer, Kenneth, Tape, Christopher, Dyson, Michael R., McCafferty, John, Murphy, Gillian, Nagase, Hideaki
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613496/
https://ncbi.nlm.nih.gov/pubmed/26303525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150758
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