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Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
Adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5 is the multi-domain metalloproteinase that most potently degrades aggrecan proteoglycan in the cartilage and its activity is implicated in the development of osteoarthritis (OA). To generate specific exosite inhibitors for...
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| 出版年: | Biochem J |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Portland Press Ltd.
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613496/ https://ncbi.nlm.nih.gov/pubmed/26303525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150758 |
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