Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis

ADAMTS (A Disintegrin-like and Metalloproteinase domain with Thrombospondin type 1 Motif)-1, -4 and -5 share the abilities to cleave large aggregating proteoglycans including versican and aggrecan. These activities are highly relevant to cardiovascular disease and osteoarthritis and during developme...

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Publicado en:Sci Rep
Autores principales: Santamaria, Salvatore, Yamamoto, Kazuhiro, Teraz-Orosz, Adrienn, Koch, Christopher, Apte, Suneel S., de Groot, Rens, Lane, David A., Ahnström, Josefin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662762/
https://ncbi.nlm.nih.gov/pubmed/31358852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47494-w
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