The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex

BACKGROUND: Activated protein C (APC)‐mediated inactivation of factor (F)Va is greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa, APC, and protein S must form on the phospholipid membrane. However, direct demonstration of complex formation has proven elusive....

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Gierula, Magdalena, Salles‐Crawley, Isabelle I., Santamaria, Salvatore, Teraz‐Orosz, Adrienn, Crawley, James T. B., Lane, David A., Ahnström, Josefin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
THROMBOSIS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916587/
https://ncbi.nlm.nih.gov/pubmed/31364267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14594
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