Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation

Tissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa. Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition. TFPI can also inhib...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Santamaria, Salvatore, Reglińska-Matveyev, Natalia, Gierula, Magdalena, Camire, Rodney M., Crawley, James T. B., Lane, David A., Ahnström, Josefin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454113/
https://ncbi.nlm.nih.gov/pubmed/28420729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769570
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