TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain

Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 4...

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Autores principales: Reglińska-Matveyev, Natalia, Andersson, Helena M., Rezende, Suely M., Dahlbäck, Björn, Crawley, James T. B., Lane, David A., Ahnström, Josefin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064334/
https://ncbi.nlm.nih.gov/pubmed/24740810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-551812
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