Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain

Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC). Despite its physiological role and clinical importance, the molecular basis of its action is not fully underst...

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Detalhes bibliográficos
Main Authors: Andersson, Helena M., Arantes, Márcia J., Crawley, James T. B., Luken, Brenda M., Tran, Sinh, Dahlbäck, Björn, Lane, David A., Rezende, Suely M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884152/
https://ncbi.nlm.nih.gov/pubmed/20308596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-256610
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