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The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function
The von Willebrand factor (VWF) A2 crystal structure has revealed the presence of a rare vicinal disulfide bond between C1669 and C1670, predicted to influence domain unfolding required for proteolysis by ADAMTS13. We prepared VWF A2 domain fragments with (A2-VicCC, residues 1473-1670) and without t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890177/ https://ncbi.nlm.nih.gov/pubmed/20354169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-257949 |
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