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The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cyste...
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| 發表在: | Blood |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366626/ https://ncbi.nlm.nih.gov/pubmed/25564400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594556 |
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