A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

ADAMTS13 metalloprotease regulates the multimeric size of von Willebrand factor (VWF) by cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF recognition by ADAMTS13 have yet to be fully resolved. Most studies have focused on the role of exosites within the VWF A2 domain, in...

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Detalhes bibliográficos
Main Authors: Zanardelli, Sara, Chion, Alain C. K., Groot, Evelyn, Lenting, Peter J., McKinnon, Thomas A. J., Laffan, Mike A., Tseng, Michelle, Lane, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402367/
https://ncbi.nlm.nih.gov/pubmed/19587373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-224915
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