Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

OBJECTIVE: The aggrecanase ADAMTS‐5 and the collagenase matrix metalloproteinase 13 (MMP‐13) are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low‐density lipoprotein receptor–related protein 1 (LRP‐1) and subsequently de...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arthritis Rheumatol
Egile Nagusiak: Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A., Dudhia, Jayesh, Troeberg, Linda, Itoh, Yoshifumi, Murphy, Gillian, Nagase, Hideaki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Osteoarthritis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449214/
https://ncbi.nlm.nih.gov/pubmed/28235248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40080
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