Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

OBJECTIVE: The aggrecanase ADAMTS‐5 and the collagenase matrix metalloproteinase 13 (MMP‐13) are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low‐density lipoprotein receptor–related protein 1 (LRP‐1) and subsequently de...

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Bibliografische gegevens
Gepubliceerd in:Arthritis Rheumatol
Hoofdauteurs: Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A., Dudhia, Jayesh, Troeberg, Linda, Itoh, Yoshifumi, Murphy, Gillian, Nagase, Hideaki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
Onderwerpen:
Osteoarthritis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449214/
https://ncbi.nlm.nih.gov/pubmed/28235248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40080
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