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Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) -4 and ADAMTS-5 are considered to be the main enzymes responsible for aggrecan breakdown, making them attractive drugs targets. Here we show th...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Federation of American Societies for Experimental Biology
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2537431/ https://ncbi.nlm.nih.gov/pubmed/18632849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-112680 |
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