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Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) -4 and ADAMTS-5 are considered to be the main enzymes responsible for aggrecan breakdown, making them attractive drugs targets. Here we show th...

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Detalhes bibliográficos
Main Authors: Troeberg, Linda, Fushimi, Kazunari, Khokha, Rama, Emonard, Hervé, Ghosh, Peter, Nagase, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2537431/
https://ncbi.nlm.nih.gov/pubmed/18632849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-112680
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