17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production

The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect. The principal product synthesized by the 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is E2, although we have demonstrated that t...

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Publicat a:Mol Endocrinol
Autors principals: Aka, Juliette A., Mazumdar, Mausumi, Chen, Chang-Qing, Poirier, Donald, Lin, Sheng-Xiang
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2010
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417535/
https://ncbi.nlm.nih.gov/pubmed/20172961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0468
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