17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production

The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect. The principal product synthesized by the 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is E2, although we have demonstrated that t...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Mol Endocrinol
Huvudupphovsmän: Aka, Juliette A., Mazumdar, Mausumi, Chen, Chang-Qing, Poirier, Donald, Lin, Sheng-Xiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2010
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417535/
https://ncbi.nlm.nih.gov/pubmed/20172961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0468
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk