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17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production
The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect. The principal product synthesized by the 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is E2, although we have demonstrated that t...
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| Publicado no: | Mol Endocrinol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417535/ https://ncbi.nlm.nih.gov/pubmed/20172961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0468 |
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