17β-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production

The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect. The principal product synthesized by the 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is E2, although we have demonstrated that t...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Endocrinol
Autori principali: Aka, Juliette A., Mazumdar, Mausumi, Chen, Chang-Qing, Poirier, Donald, Lin, Sheng-Xiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2010
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417535/
https://ncbi.nlm.nih.gov/pubmed/20172961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0468
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi