Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of electrolyte balance and blood pressure. Excess aldosterone levels can arise from dysregulation of the renin-angiotensin-aldosterone system and are implicated in the pathogenesis of hypertension and heart fail...

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Detalles Bibliográficos
Publicado en:Mol Endocrinol
Main Authors: Strushkevich, Natallia, Gilep, Andrei A., Shen, Limin, Arrowsmith, Cheryl H., Edwards, Aled M., Usanov, Sergey A., Park, Hee-Won
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2013
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417327/
https://ncbi.nlm.nih.gov/pubmed/23322723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1287
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