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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin (Adx), and a cytochrome P450 (P450scc or CYP11A1). This complex not only plays a key role in steroidogenesis, but also has long bee...

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Detalhes bibliográficos
Main Authors: Strushkevich, Natallia, MacKenzie, Farrell, Cherkesova, Tatyana, Grabovec, Irina, Usanov, Sergey, Park, Hee-Won
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121847/
https://ncbi.nlm.nih.gov/pubmed/21636783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019441108
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