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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin (Adx), and a cytochrome P450 (P450scc or CYP11A1). This complex not only plays a key role in steroidogenesis, but also has long bee...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121847/ https://ncbi.nlm.nih.gov/pubmed/21636783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019441108 |
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