Evidence that Compound I is the active species in both the hydroxylase and lyase steps by which P450scc converts cholesterol to pregnenolone: EPR/ENDOR/cryoreduction/annealing studies

Cytochrome P450scc (CYP 11A1) catalyzes the conversion of cholesterol (Ch) to pregnenolone, the precursor to steroid hormones. This process proceeds via three sequential monooxygenation reactions: two hydroxylations of Ch first form 22R-hydroxycholesterol (HC) and then 20α,22R-dihydroxycholesterol (...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Davydov, Roman, Strushkevich, Natallia, Smil, David, Yantsevich, Aliaksei, Gilep, Andrey, Usanov, Sergey, Hoffman, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732517/
https://ncbi.nlm.nih.gov/pubmed/26603348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00903
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