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Evidence that Compound I is the active species in both the hydroxylase and lyase steps by which P450scc converts cholesterol to pregnenolone: EPR/ENDOR/cryoreduction/annealing studies
Cytochrome P450scc (CYP 11A1) catalyzes the conversion of cholesterol (Ch) to pregnenolone, the precursor to steroid hormones. This process proceeds via three sequential monooxygenation reactions: two hydroxylations of Ch first form 22R-hydroxycholesterol (HC) and then 20α,22R-dihydroxycholesterol (...
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| Publicat a: | Biochemistry |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732517/ https://ncbi.nlm.nih.gov/pubmed/26603348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00903 |
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