Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

The vasculature of the central nervous system (CNS) forms a selective barrier termed the blood–brain barrier (BBB). Disruption of the BBB may contribute to various CNS diseases. Conversely, the intact BBB restricts efficient penetration of CNS-targeted drugs. Here, we report the BBB-regulatory role...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Yanagida, Keisuke, Liu, Catherine H., Faraco, Giuseppe, Galvani, Sylvain, Smith, Helen K., Burg, Nathalie, Anrather, Josef, Sanchez, Teresa, Iadecola, Costantino, Hla, Timothy
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410849/
https://ncbi.nlm.nih.gov/pubmed/28396408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618659114
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