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COX-1-derived prostaglandin E(2) and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II

Prostaglandin E(2) (PGE(2) ) EP1 receptors (EP1R) may contribute to hypertension and related end-organ damage. Because of the key role of angiotensin II (AngII) in hypertension, we investigated the role of EP1R in the cerebrovascular alterations induced by AngII. Mice were equipped with a cranial wi...

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Detalhes bibliográficos
Main Authors: Capone, Carmen, Faraco, Giuseppe, Anrather, Josef, Zhou, Ping, Iadecola, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861995/
https://ncbi.nlm.nih.gov/pubmed/20194308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.145813
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