Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity

Imidazole glycerol phosphate synthase (IGPS) is a V-type allosteric enzyme, meaning that its catalytic rate is critically dependent on activation by its allosteric ligand, N′-[(5′-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (PRFAR). The allosteric mechanism of IGPS is r...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Lisi, George P., East, Kyle W., Batista, Victor S., Loria, J. Patrick
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410785/
https://ncbi.nlm.nih.gov/pubmed/28396388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700448114
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