Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity

Imidazole glycerol phosphate synthase (IGPS) is a V-type allosteric enzyme, meaning that its catalytic rate is critically dependent on activation by its allosteric ligand, N′-[(5′-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (PRFAR). The allosteric mechanism of IGPS is r...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lisi, George P., East, Kyle W., Batista, Victor S., Loria, J. Patrick
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410785/
https://ncbi.nlm.nih.gov/pubmed/28396388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700448114
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