Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Histone deacetylase (HDAC) inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, each of these drugs inhibits multiple HDACs and has detrimental effects on the skeleton. To better understand how HDAC inhibitors affect endochondral bone formation,...

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Publicado en:Sci Signal
Autores principales: Carpio, Lomeli R., Bradley, Elizabeth W., McGee-Lawrence, Meghan E., Weivoda, Megan M., Poston, Daniel D., Dudakovic, Amel, Xu, Ming, Tchkonia, Tamar, Kirkland, James L., van Wijnen, Andre J., Oursler, Merry Jo, Westendorf, Jennifer J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409103/
https://ncbi.nlm.nih.gov/pubmed/27507649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf3273
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