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PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8(+) T cells
Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses. The interaction of PD-L1 with CD80 alone has been shown to exacerbate the severity of graft-versus-host disease (GVHD), where...
Guardat en:
| Publicat a: | J Clin Invest |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409099/ https://ncbi.nlm.nih.gov/pubmed/28414296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91138 |
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