PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8(+) T cells

Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses. The interaction of PD-L1 with CD80 alone has been shown to exacerbate the severity of graft-versus-host disease (GVHD), where...

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Udgivet i:J Clin Invest
Main Authors: Ni, Xiong, Song, Qingxiao, Cassady, Kaniel, Deng, Ruishu, Jin, Hua, Zhang, Mingfeng, Dong, Haidong, Forman, Stephen, Martin, Paul J., Chen, Yuan-Zhong, Wang, Jianmin, Zeng, Defu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409099/
https://ncbi.nlm.nih.gov/pubmed/28414296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91138
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