Depletion of host CCR7(+) Dendritic Cells Prevented Donor T cell Tissue Tropism in Anti-CD3-Conditioned Recipients

We reported previously that anti-CD3 mAb treatment before HCT prevented graft versus host disease (GVHD) and preserved graft-versus-leukemia (GVL) effects in mice. These effects were associated with down-regulated donor T cell expression of tissue-specific homing and chemokine receptors, marked redu...

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Main Authors: He, Wei, Racine, Jeremy J., Johnston, Heather F., Li, Xiaofan, Li, Nainong, Cassady, Kaniel, Liu, Can, Deng, Ruishu, Martin, Paul, Forman, Stephen, Zeng, Defu
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057972/
https://ncbi.nlm.nih.gov/pubmed/24691220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2014.03.029
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