Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI

Host dendritic cells (DCs) play a critical role in initiating graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL), and separation of GVL from GVHD remains a major challenge in the treatment of hematologic malignancies by allogeneic hematopoietic cell transplantation (HCT). Here, we show...

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Main Authors: Li, Nainong, Chen, Ying, He, Wei, Yi, Tangsheng, Zhao, Dongchang, Zhang, Chunyan, Lin, Chia-Lei, Todorov, Ivan, Kandeel, Fouad, Forman, Stephen, Zeng, Defu
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630281/
https://ncbi.nlm.nih.gov/pubmed/18922852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-165522
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